Gene content    
NUP214 ( by HUGO)
Nucleoporin
Other
Nucleoporin 214kDa
CAIN
CAN
Nuclear Pore Complex Protein Nup214
D9S46E
CAN Protein
Nucleoporin 214kD (CAIN)
Putative Oncogene
N214
CAN Protein
Putative Oncogene
p250
214 KDa Nucleoporin
KIAA0023
Nucleoporin Nup214
Protein CAN
NCBI: 9q34.1    Ensembl: 9q34.13
NU214_HUMANSize: 2090 amino acidsMass: 213620 Da

  • Subunit: Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore Sequence caution: Sequence=BAD07398.1; Type=Erroneous initiation; 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for NUP214: 2OIT (3D) [IMAGE] 3FHC (3D) [IMAGE] 3FMO (3D) [IMAGE] 3FMP (3D) [IMAGE]
  • Tissue specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development [IMAGE] Custom PCR Arrays for NUP214 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for N
  • Function:
    UniProtKB/Swiss-Prot Summary: NU214_HUMAN, P35658 Function: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001680WD40_repeatWD-40 repeatRepeat

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process protein export from nucleus IMP GOA 12191473
    Molecular Function protein binding IPI GOA 11545741
    transporter activity TAS GOA 8108440

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET
    SWISS-PROTNote=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene

    NUP214 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene