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Subunit: Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for PARD6A: 1WMH (3D) [IMAGE]
Tissue specificity: Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including PARD6A: Tight Junctions in human mouse rat Stem Cells in human mouse rat Primer Products:
Function: UniProtKB/Swiss-Prot Summary: PAR6A_HUMAN, Q9NPB6 Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005080 protein kinase C binding IEA -- GO:0005515 protein binding IPI 10934474 GO:0008134 transcription factor binding TAS 9482110 GO:0017048 Rho GTPase binding ISS -- GO:0030742 GTP-dependent protein binding ISS -- [IMAGE] Find genes that share ontologies with PARD6A About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for PARD6A: Increased circadian period len Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARD6A [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARD6A [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARD6A [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARD6A miRNA Products: miRTarBase miRNAs that target PARD6A: hsa-mir-595 (MIRT006685) [IMAGE] Block miRNA regulation of human, mouse, rat PARD6A using miScript Target Protectors [IMAGE] 3 qRT-PCR Assays for microRNAs that regulate PARD6A: hsa-miR-33a* hsa-miR-409-3p hsa-miR-3674 [IMAGE] Browse SwitchGear 3'UTR luciferase reporter plasmids Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for PARD6A [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat PARD6A Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for PARD6A Clone Products: [IMAGE] OriGene clones in human, mouse for PARD6A (see all 14) OriGene ORF clones in mouse, rat for PARD6A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 2): PARD6A (NM_016948) [IMAGE] Sino Biological Human cDNA Clone for PARD6A [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARD6A [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARD6A [IMAGE] Addgene plasmids for PARD6A [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for PARD6A [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for PARD6A [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARD6A Flow Cytometry Products: [IMAGE] eBioscience FlowRNA Probe Sets (VA1-12013) for PARD6A [IMAGE]
Similarity: Belongs to the PAR6 family Contains 1 OPR domain Contains 1 PDZ (DHR) domain Contains 1 pseudo-CRIB domain [IMAGE]
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