Gene content    
PATZ1 ( by HUGO)
POZ (BTB) And AT Hook Containing Zinc Finger 1
Oncogene
POZ (BTB) And AT Hook Containing Zinc Finger 1
ZNF278
Zinc Finger Protein 278
PATZ
Protein Kinase A RI Subunit Alpha-Associated Protein
Zinc Finger And BTB Domain-Containing Protein 19
Zinc Finger Sarcoma Gene Protein
RIAZ
ZBTB19
ZSG
BTB/POZ Domain Zinc Finger Transcription Factor
MAZR
BTB-POZ Domain Zinc Finger Transcription Factor
dJ400N23
MAZ-Related Factor
POZ-
AT Hook-
And Zinc Finger-Containing Protein 1
POZ-AT Hook-Zinc Finger Protein
NCBI: 22q12.2    Ensembl: 22q12.2
PATZ1_HUMANSize: 687 amino acidsMass: 74060 Da

  • Tissue specificity: Ubiquitous [IMAGE] Custom PCR Arrays for PATZ1 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for PATZ1 OriGene qSTAR qPCR primer pairs in human, mouse for PATZ1 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P
  • Function:
    UniProtKB/Swiss-Prot Summary: PATZ1_HUMAN, Q9HBE1 Function: Transcriptional repressor Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding NAS 10949935 GO:0003682 chromatin binding IEA -- GO:0005515 protein binding -- -- GO:0046872 metal ion binding IEA -- [IMAGE] Find genes that share ontologies with PATZ1 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for PATZ1: Synthetic lethal with Ras
  • Similarity:
    Belongs to the krueppel C2H2-type zinc-finger protein family
                          
    Contains 1 A.T hook DNA-binding domain
                          
    Contains 1 BTB (POZ) domain
                          
    Contains 7 C2H2-type zinc fingers [IMAGE]
  • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000210BTB/POZ-likeBTB/POZDomain
    IPR000637HMGI/Y_DNA-bd_CSHMG-I and HMG-Y, DNA-bindingDomain
    IPR007087Znf_C2H2Zinc finger, C2H2-typeDomain
    BlocksIPB000210BTB/POZ domainBTB/POZ domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of transcription, DNA-templated TAS GOA 10713105
    regulation of transcription, DNA-templated TAS GOA 10713105
    Cellular Component nucleus TAS GOA 10713105
    Molecular Function DNA binding NAS GOA 10949935

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1

    PATZ1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene