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Subunit: Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1 and TLX1. Isoform PBX1a interacts with MEIS2 isoform 4, SP1, SP3 and KLF4. Isoform PBX1b is part of a PDX1:PBX1b:MEIS2b complex; PBX1b recruits Meis2B to the complex Sequence caution: Sequence=AAA36764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PBX1: 1B72 (3D) [IMAGE] 1PUF (3D) [IMAGE]
Tissue specificity: Expressed in all tissues except in cells of the B and T lineage [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PBX1: Notch Signaling Targets in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards f
Function: UniProtKB/Swiss-Prot Summary: PBX1_HUMAN, P40424 Function: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity)
Similarity: Belongs to the TALE/PBX homeobox family Contains 1 homeobox DNA-binding domain [IMAGE]
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