Gene content    
PCGF4 (approved by HUGO)
polycomb group ring finger 4
Oncogene
BMI1
MGC12685
RNF51
NCBI: 10p11.23    Ensembl: 10p12.2
PCGF4_HUMANSize: 326 amino acidsMass: 36949 Da

  • Subcellular location: Nucleus
  • Subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, PCGF4/BMI1, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1- like at least composed of PHC2, PCGF4, RING1 and RNF2
  • Function:
    Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility
  • Similarity:
    Contains 1 RING-type zinc finger.

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001841Znf_RINGZinc finger, RING-typeDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process chromatin modification IEA GOA
    metal ion binding IEA GOA
    nucleus IEA GOA
    protein binding IEA GOA
    zinc ion binding IEA GOA
    Cellular Component segment specification TAS GOA PubMed
    Molecular Function regulation of transcription, DNA-dependent IEA GOA
    transcription IEA GOA

    PCGF4 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene