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Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity) 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PDGFB: 1PDG (3D) [IMAGE] 3MJG (3D) [IMAGE] 4HQU (3D) [IMAGE] 4HQX (3D) [IMAGE]
Tissue specificity: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including PDGFB
Function: UniProtKB/Swiss-Prot Summary: PDGFB_HUMAN, P01127 Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)
Similarity: Belongs to the PDGF/VEGF growth factor family [IMAGE]
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