Gene content
Symbol	PDGFRL ( by HUGO)
Name	Platelet-Derived Growth Factor Receptor-Like
Category	Tumor suppressor gene
Alias	Platelet-Derived Growth Factor Receptor-Like PRLTS PDGF Receptor Beta-Like Tumor Suppressor PDGFR-Like Protein PDGRL Platelet-Derived Growth Factor Receptor-Like Protein Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor
Cytogenetic band	NCBI: 8p22-p21.3    Ensembl: 8p22
Protein information	PGFRL_HUMAN Size: 375 amino acids Mass: 41861 Da Subunit: Forms a complex composed of PDGFRL, TNK2 and GRB2 Tissue specificity: Expressed in colon, lung and liver [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PDGFRL: G Protein Coupled Receptors 384HT in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for PDGFRL OriGene Function: Genatlas biochemistry entry for PDGFRL: platelet-derived growth factor receptor-like Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004992 platelet activating factor receptor activity TAS 7898930 GO:0005019 platelet-derived growth factor beta-receptor activity TAS 7898930 GO:0005515 protein binding -- -- [IMAGE] Find genes that share ontologies with PDGFRL About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for PDGFRL: Decreased influenza A/WSN/33 r Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDGFRL [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDGFRL [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDGFRL [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDGFRL miRNA Products: miRTarBase miRNAs that target PDGFRL: hsa-mir-26b-5p (MIRT029428), hsa-mir-25-3p (MIRT050268) [IMAGE] Block miRNA regulation of human, mouse, rat PDGFRL using miScript Target Protectors [IMAGE] 3 qRT-PCR Assays for microRNAs that regulate PDGFRL: hsa-miR-3163 hsa-miR-633 hsa-miR-617 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: PDGFRL 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for PDGFRL [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat PDGFRL Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for PDGFRL Clone Products: [IMAGE] OriGene clones in human, mouse for PDGFRL (see all 7) OriGene ORF clones in mouse, rat for PDGFRL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: PDGFRL (NM_006207) [IMAGE] Sino Biological Human cDNA Clone for PDGFRL [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRL [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRL [IMAGE] Addgene plasmids for PDGFRL [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for PDGFRL [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for PDGFRL [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRL Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR003599	Ig_sub	Immunoglobulin subtype	Domain
	IPR007110	Ig-like_dom	Immunoglobulin-like	Domain
	IPR013098	Ig_I-set	Immunoglobulin I-set	Domain
Blocks	IPB003599	Immunoglobulin subtype	Immunoglobulin subtype

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	G-protein coupled receptor signaling pathway	TAS	GOA	7898930
Molecular Function	platelet activating factor receptor activity	TAS	GOA	7898930
	platelet-derived growth factor beta-receptor activity	TAS	GOA	7898930

Disorder & Mutation
Source	Disease
SWISS-PROT	Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry is involved in disease pathogenesis
SWISS-PROT	Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:19815557). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract

PDGFRL cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene