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Subunit: Homodimer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1 (By similarity). Binding to CSNK1G2 triggers proteasomal degradation Sequence caution: Sequence=BAC06326.2; Type=Erroneous initiation; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for PER1: 1UL6 (3D) [IMAGE]
Tissue specificity: Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney [IMAGE] Pathway & Disease-focused RT2 Pro
Function: UniProtKB/Swiss-Prot Summary: PER1_HUMAN, O15534 Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. Can bind heme (By similarity)
Similarity: Contains 1 PAC (PAS-associated C-terminal) domain Contains 2 PAS (PER-ARNT-SIM) domains [IMAGE]
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