Gene content    
PHB ( by HUGO)
Prohibitin
Tumor suppressor gene
prohibitin
HEL-215
HEL-S-54e
PHB1
Epididymis Luminal Protein 215
Epididymis Secretory Sperm Binding Protein Li 54e
NCBI: 17q21    Ensembl: 17q21.33
PHB_HUMANSize: 272 amino acidsMass: 29804 Da

  • Subunit: Interacts with PHB2. Interacts with STOML2 Developmental stage: Levels of expression in fibroblasts decrease heterogeneously during cellular aging 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for PHB: 1LU7 (3D) [IMAGE]
  • Tissue specificity: Widely expressed in different tissues [IMAGE] Custom PCR Arrays for PHB Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for PHB OriGene qSTAR qPCR primer pairs in human, mouse for PHB [IMAGE] Pre-validated RT2 qPCR Primer Assay i
  • Function:
    UniProtKB/Swiss-Prot Summary: PHB_HUMAN, P35232 Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging
  • Similarity:
    Belongs to the prohibitin family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000163ProhibitinProhibitinFamily
    IPR001107Band_7Band 7 proteinFamily
    BlocksIPB000163Prohibitin signatureProhibitin signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cellular response to interleukin-6 IDA GOA 17324931
    histone deacetylation IDA GOA 12466959
    negative regulation of androgen receptor signaling pathway IMP GOA 18487222
    negative regulation of androgen receptor signaling pathway IDA GOA 16964284
    negative regulation of cell growth IMP GOA 12065415
    negative regulation of cell proliferation IMP GOA 18487222
    negative regulation of transcription by competitive promoter binding IDA GOA 18487222
    negative regulation of transcription from RNA polymerase II promoter IDA GOA 16964284
    negative regulation of transcription, DNA-templated IMP GOA 18487222
    negative regulation of transcription, DNA-templated IDA GOA 12065415
    osteoblast differentiation IDA GOA 16210410
    positive regulation of transcription, DNA-templated IDA GOA 14500729
    progesterone receptor signaling pathway IDA GOA 16964284
    regulation of apoptotic process TAS GOA 16130169
    regulation of transcription, DNA-templated IDA GOA 14500729
    signal transduction TAS GOA 16130169
    Cellular Component cytoplasm IDA GOA 16964284
    integral component of plasma membrane IDA GOA 15274632
    membrane IDA GOA 16210410
    mitochondrial inner membrane TAS GOA 14500729
    nucleoplasm IDA GOA 12466959
    nucleus IDA GOA 16964284
    nucleus TAS GOA 16130169
    Molecular Function histone deacetylase binding IPI GOA 16964284
    protein binding IPI GOA 11302691
    transcription regulatory region DNA binding IDA GOA 18487222

    PHB cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene