Gene content  |
| PIN1 ( by HUGO) |
| Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1 |
| Oncogene |
| Peptidylprolyl Cis/Trans Isomerase NIMA-Interacting 1 Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting 1 Rotamase Pin1 PPIase Pin1 EC 5.2.1.8 DOD UBL5 Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 Peptidyl-Prolyl Cis-Trans Isomerase Pin1 |
| NCBI: 19p13 Ensembl: 19p13.2 |
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Subunit: Interacts with STIL. Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML (isoform PML-4) and BCL-6 Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PIN1 (see all 55): 1F8A (3D) [IMAGE] 1I6C (3D) [IMAGE] 1I8G (3D) [IMAGE] 1I8H (3D) [IMAGE] 1NMV (3D) [IMAGE] 1NMW (3D) [IMAGE]
Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including PIN1: Antiviral Response in human mouse rat Liver Cancer in human mouse rat Pri
Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
Similarity: Contains 1 PpiC domain Contains 1 WW domain [IMAGE]
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