Gene content    
PLA2G2A ( by HUGO)
Phospholipase A2, Group IIA (Platelets, Synovial Fluid)
Tumor suppressor gene
Phospholipase A2
Group IIA (Platelets
Synovial Fluid)
PLA2B
PLA2L
Group IIA Phospholipase A2
Non-Pancreatic Secretory Phospholipase A2
Phosphatidylcholine 2-Acylhydrolase 2A
NPS-PLA2
GIIC SPLA2
MOM1
PLA2
PLA2S
PLAS1
Phospholipase A2
Membrane Associated
sPLA2
EC 3.1.1.4
RASF-A
NCBI: 1p35    Ensembl: 1p36.13
PA2GA_HUMANSize: 144 amino acidsMass: 16083 Da

  • Function:
    Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
                          
    Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
  • Catalytic activity:
    Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
  • Similarity:
    Belongs to the phospholipase A2 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001211PLipase_A2Phospholipase A2Family
    BlocksIPB001211Phospholipase A2Phospholipase A2

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process defense response to Gram-positive bacterium TAS GOA 18827909
    low-density lipoprotein particle remodeling TAS GOA 18827909
    phosphatidic acid metabolic process IDA GOA 9032461
    phospholipid metabolic process IDA GOA 17069818
    positive regulation of inflammatory response TAS GOA 18827909
    positive regulation of macrophage derived foam cell differentiation TAS GOA 18827909
    Cellular Component extracellular space IDA GOA 17069818
    Molecular Function calcium-dependent phospholipase A2 activity TAS GOA 9272153
    phospholipase A2 activity IDA GOA 17069818
    phospholipid binding IDA GOA 9032461

    PLA2G2A cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene