TAG for PLCD1

Gene content

Symbol

PLCD1 ( by HUGO)

Name

Phospholipase C, Delta 1

Category

Tumor suppressor gene

Alias

Phospholipase C
Delta 1
Phosphoinositide Phospholipase C-Delta-1
Phospholipase C-III
PLC-III
PLC-delta-1
EC 3.1.4.11
NDNC3
1-Phosphatidylinositol 4
5-Bisphosphate Phosphodiesterase Delta-1
1-Phosphatidylinositol-4
5-Bisphosphate Phosphodiesterase Delta-1
Phospholipase C-Delta-1

Cytogenetic band

NCBI: 3p22-p21.3 Ensembl: 3p22.2

Protein information

PLCD1_HUMAN

Size: 756 amino acids

Mass: 85665 Da

Function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development

Catalytic activity:

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Similarity:

Contains 1 C2 domain

Contains 2 EF-hand domains

Contains 1 PH domain

Contains 1 PI-PLC X-box domain

Contains 1 PI-PLC Y-box domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000008	C2_dom	C2	Domain
	IPR000909	PLipase_C_PInositol-sp_X_dom	Phosphatidylinositol-specific phospholipase C, X region	Domain
	IPR001192	PI-PLC_fam	Phosphoinositide-specific phospholipase C (PLC)	Family
	IPR001711	PLipase_C_Pinositol-sp_Y	Phosphatidylinositol-specific phospholipase C, Y domain	Domain
	IPR001849	Pleckstrin_homology	Pleckstrin-like	Domain
	IPR002048	EF_hand_dom	Calcium-binding EF-hand	Domain
	IPR011992	EF-hand-dom_pair	EF-Hand type	Domain
	IPR011993	PH_like_dom	Pleckstrin homology-type	Domain
Blocks	IPB000909	Phosphatidylinositol-specific phospholipase C	Phosphatidylinositol-specific phospholipase C, X domain
Blocks	IPB001849	Pleckstrin-like	Pleckstrin-like

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	phospholipid metabolic process	TAS	GOA	9588182
Cellular Component	cytoplasm	IDA	GOA	15702972
Cellular Component	extracellular vesicular exosome	IDA	GOA	19056867
Molecular Function	GTPase activating protein binding	IPI	GOA	18434237

Disorder & Mutation
Source	Disease
SWISS-PROT	Nail disorder, non-syndromic congenital, 3 (NDNC3) [MIM:151600]: A nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). Note=The disease is caused by mutations affecting the gene represented in this entry

PLCD1 cross reference