Gene content
Symbol	PMAIP1 ( by HUGO)
Name	Phorbol-12-Myristate-13-Acetate-Induced Protein 1
Category	Other
Alias	Phorbol-12-Myristate-13-Acetate-Induced Protein 1 Immediate-Early-Response Protein APR Protein Noxa NOXA PMA-Induced Protein 1 APR Adult T Cell Leukemia-Derived PMA-Responsive
Cytogenetic band	NCBI: 18q21.32    Ensembl: 18q21.32
Protein information	APR_HUMAN Size: 54 amino acids Mass: 6030 Da Subunit: Interacts with MCL1, BCL2A1 and BAX 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for PMAIP1: 3MQP (3D) [IMAGE] Tissue specificity: Highly expressed in adult T-cell leukemia cell line [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including PMAIP1: cAMP / Ca2+ Signaling PathwayFinder in human mouse rat Mitochondria in human mouse rat Apoptosis 384HT in human mouse rat Prime Function: UniProtKB/Swiss-Prot Summary: APR_HUMAN, Q13794 Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 Similarity: Belongs to the PMAIP1 family [IMAGE]

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	apoptotic process	IMP	GOA	17599062
	cellular response to hypoxia	IEP	GOA	14699081
	defense response to virus	IDA	GOA	15705586
	negative regulation of mitochondrial membrane potential	ISS	GOA	14699081
	positive regulation of apoptotic process	IMP	GOA	17289999
	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	GOA	14699081
	positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP	GOA	15102863
	positive regulation of protein oligomerization	IDA	GOA	17024184
	positive regulation of release of cytochrome c from mitochondria	IDA	GOA	14500711
	positive regulation of release of cytochrome c from mitochondria	IMP	GOA	15705586
	proteasomal protein catabolic process	IDA	GOA	15901672
	regulation of mitochondrial membrane permeability	IDA	GOA	14500711
	response to dsRNA	IDA	GOA	15705586
Cellular Component	cytosol	IDA	GOA	15705586
	mitochondrion	IDA	GOA	14500711
	nucleus	IDA	GOA	12879012
Molecular Function	protein binding	IPI	GOA	15705586

PMAIP1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene