Gene content  |
| PPP1R3C ( by HUGO) |
| Protein Phosphatase 1, Regulatory Subunit 3C |
| Tumor suppressor gene |
| Protein Phosphatase 1 Regulatory Subunit 3C PPP1R5 Protein Targeting To Glycogen Protein Phosphatase 1 Regulatory (Inhibitor) Subunit 3C Protein Phosphatase 1 Regulatory Subunit 5 PTG PP1 Subunit R5 Phosphatase 1 Regulatory Inhibitor Subunit 5 Phosphatase 1 Regulatory Inhibitor Subunit 5 Protein Phosphatase 1 Regulatory Subunit 3C |
| NCBI: 10q23-q24 Ensembl: 10q23.32 |
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Subunit: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin Sequence caution: Sequence=AAD33215.1; Type=Erroneous gene model prediction;
Function: UniProtKB/Swiss-Prot Summary: PPR3C_HUMAN, Q9UQK1 Function: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004722 protein serine/threonine phosphatase activity TAS 8985175 GO:0005515 protein binding IPI 14532330 GO:0019903 protein phosphatase binding IEA -- [IMAGE] Find genes that share ontologies with PPP1R3C About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for PPP1R3C: Decreased focal adhesion (FA)
Similarity: Contains 1 CBM21 (carbohydrate binding type-21) domain [IMAGE]
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