Gene content    
PRDM1 ( by HUGO)
PR Domain Containing 1, With ZNF Domain
Tumor suppressor gene
PR Domain Containing 1
With ZNF Domain
BLIMP1
BLIMP-1
PRDI-BF1
B-Lymphocyte-Induced Maturation Protein 1
Beta-Interferon Gene Positive-Regulatory Domain I Binding Factor
PR Domain Zinc Finger Protein 1
PRDI-Binding Factor-1
EC 2.1.1.-
Beta-Interferon Gene Positive Regulatory Domain I-Binding Factor
Positive Regulatory Domain I-Binding Factor 1
PR Domain-Containing Protein 1
PRDI-Binding Factor 1
NCBI: 6q21    Ensembl: 6q21
PRDM1_HUMANSize: 825 amino acidsMass: 91771 Da

  • Subunit: Interacts with PRMT5 (By similarity) Sequence caution: Sequence=AAO45623.1; Type=Erroneous initiation; Note=Translation N-terminally extended; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for PRDM1: 3DAL (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: PRDM1_HUMAN, O75626 Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells
  • Similarity:
    Belongs to the class V-like SAM-binding methyltransferase superfamily
                          
    Contains 4 C2H2-type zinc fingers
                          
    Contains 1 SET domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001214SET_domNuclear protein SETDomain
    IPR007087Znf_C2H2Zinc finger, C2H2-typeDomain
    BlocksIPB007086C2H2-type zinc finger signatureC2H2-type zinc finger signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Molecular Function sequence-specific DNA binding transcription factor activity TAS GOA 1851123

    PRDM1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene