Gene content
Symbol	PROX1 ( by HUGO)
Name	Prospero Homeobox 1
Category	Tumor suppressor gene
Alias	Prospero Homeobox 1 Prospero-Related Homeobox 1 Homeobox Prospero-Like Protein PROX1 Prospero Homeobox Protein 1 PROX-1
Cytogenetic band	NCBI: 1q41    Ensembl: 1q32.3
Protein information	PROX1_HUMAN Size: 737 amino acids Mass: 83203 Da Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas [IMAGE] Pathway & Disease-focused RT2 Profiler P Function: UniProtKB/Swiss-Prot Summary: PROX1_HUMAN, Q92786 Function: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity) Similarity: Belongs to the Prospero homeobox family                        Contains 1 Prospero-type homeobox DNA-binding domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR007738	Prox1	Homeobox prospero-like	Family
	IPR009057	Homeodomain-like	Homeodomain-like	Domain
Blocks	IPB007738	Homeobox prospero-like	Homeobox prospero-like

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	brain development	IEP	GOA	8812486
	dorsal spinal cord development	ISS	GOA	11789987
	embryonic retina morphogenesis in camera-type eye	IEP	GOA	12692551
	hepatocyte differentiation	IEP	GOA	15232737
	kidney development	IEP	GOA	8812486
	lens development in camera-type eye	IEP	GOA	8812486
	lens fiber cell morphogenesis	IEP	GOA	11850194
	liver development	IEP	GOA	11789987
	lung development	IEP	GOA	8812486
	lymphangiogenesis	IDA	GOA	12412020
	lymphatic endothelial cell differentiation	IDA	GOA	12198161
	negative regulation of bile acid biosynthetic process	IMP	GOA	16488887
	negative regulation of cell proliferation	IMP	GOA	17062673
	negative regulation of sequence-specific DNA binding transcription factor activity	IDA	GOA	15205472
	negative regulation of transcription from RNA polymerase II promoter	IDA	GOA	15205472
	negative regulation of transcription, DNA-templated	IMP	GOA	16488887
	negative regulation of transcription, DNA-templated	IDA	GOA	15143342
	negative regulation of viral genome replication	IDA	GOA	19264593
	neural tube development	ISS	GOA	11789987
	olfactory placode formation	ISS	GOA	11789987
	optic placode formation involved in camera-type eye formation	ISS	GOA	11850194
	otic placode formation	ISS	GOA	11789987
	pancreas development	IEP	GOA	11789987
	positive regulation of cell proliferation	IDA	GOA	12198161
	positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	GOA	19210544
	positive regulation of endothelial cell migration	IDA	GOA	19210544
	positive regulation of endothelial cell proliferation	IDA	GOA	19210544
	positive regulation of transcription, DNA-templated	IMP	GOA	18815287
	regulation of gene expression	IDA	GOA	12198161
	regulation of transcription involved in lymphatic endothelial cell fate commitment	IMP	GOA	18815287
	retina morphogenesis in camera-type eye	ISS	GOA	11789987
Cellular Component	cytoplasm	IDA	GOA	11850194
	nucleus	IDA	GOA	11850194
Molecular Function	DBD domain binding	IPI	GOA	15205472
	DNA binding	IMP	GOA	18815287
	LBD domain binding	IPI	GOA	15143342
	ligand-dependent nuclear receptor binding	IPI	GOA	15143342
	protein binding	IPI	GOA	18815287
	sequence-specific DNA binding transcription factor activity	IC	GOA	19210544
	transcription corepressor activity	IDA	GOA	15143342
	transcription regulatory region DNA binding	IDA	GOA	19210544

PROX1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene