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Subunit: PTHrP interacts with PTH1R (via N-terminal extracellular domain) 5 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTHLH: 1BZG (3D) [IMAGE] 1ET3 (3D) [IMAGE] 1M5N (3D) [IMAGE] 3FFD (3D) [IMAGE] 3H3G (3D) [IMAGE]
Tissue specificity: Ubiquitous. Also expressed in the mammary gland [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PTHLH: TGFB Signaling Targets in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for PTHLH OriGene
Function: UniProtKB/Swiss-Prot Summary: PTHR_HUMAN, P12272 Function: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 Function: Osteostatin is a potent inhibitor of osteoclastic bone resorption
Similarity: Belongs to the parathyroid hormone family [IMAGE]
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