Gene content    
PTP4A1 ( by HUGO)
Protein Tyrosine Phosphatase Type IVA, Member 1
Other
Protein Tyrosine Phosphatase Type IVA
Member 1
PRL1
Protein-Tyrosine Phosphatase 4a1
Protein-Tyrosine Phosphatase Of Regenerating Liver 1
PRL-1
PTPCAAX1
EC 3.1.3.48
HH72
PTP(CAAX1)
Protein Tyrosine Phosphatase Type IVA 1
Protein Tyrosine Phosphatase Type IVA Protein 1
PTP(CAAXI)
NCBI: 6q12    Ensembl: 6q12
TP4A1_HUMANSize: 173 amino acidsMass: 19815 Da

  • Subunit: Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin Developmental stage: Expressed in fetal liver 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTP4A1: 1RXD (3D) [IMAGE] 1XM2 (3D) [IMAGE]
  • Tissue specificity: Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including PTP4A1: Protein Phosphatases in human mouse rat Epithelial to Mesenchyma
  • Function:
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis
                          
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Enzyme regulation: Inhibited by sodium orthovanadate and pentamidine
  • Catalytic activity:
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Enzyme regulation: Inhibited by sodium orthovanadate and pentamidine
  • Similarity:
    Belongs to the protein-tyrosine phosphatase family
                          
    Contains 1 tyrosine-protein phosphatase domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000242Tyr_Pase_rcpt/non-rcptTyrosine specific protein phosphataseDomain
    IPR000387Tyr/Dual-sp_PaseTyrosine specific protein phosphatase and dual specificity protein phosphataseDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Cellular Component cytoplasm IDA GOA 10940933
    cytoplasmic side of plasma membrane IDA GOA 10940933
    Molecular Function protein tyrosine phosphatase activity NAS GOA 10569806

    PTP4A1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene