Gene content    
PTPN12 ( by HUGO)
Protein Tyrosine Phosphatase, Non-Receptor Type 12
Tumor suppressor gene
Protein Tyrosine Phosphatase
Non-Receptor Type 12
PTPG1
Protein-Tyrosine Phosphatase G1
PTP-PEST
Tyrosine-Protein Phosphatase Non-Receptor Type 12
EC 3.1.3.48
NCBI: 7q11.23    Ensembl: 7q11.23
PTN12_HUMANSize: 780 amino acidsMass: 88106 Da

  • Subunit: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity) Sequence caution: Sequence=BAD92761.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
  • Function:
    Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2
                          
    Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2
  • Catalytic activity:
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
  • Similarity:
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily
                          
    Contains 1 tyrosine-protein phosphatase domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000242Tyr_Pase_rcpt/non-rcptTyrosine specific protein phosphataseDomain
    IPR000387Tyr/Dual-sp_PaseTyrosine specific protein phosphatase and dual specificity protein phosphataseDomain
    IPR012266Ptpn_12Protein-tyrosine phosphatase, non-receptor 12Family
    BlocksIPB000242Protein tyrosine phosphatase signatureProtein tyrosine phosphatase signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process protein dephosphorylation TAS GOA 8454633
    Molecular Function non-membrane spanning protein tyrosine phosphatase activity TAS GOA 8454633
    protein binding IPI GOA 12614164
    SH3 domain binding IPI GOA 9285683

    PTPN12 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene