Gene content  |
| PTPN13 ( by HUGO) |
| Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95... |
| Tumor suppressor gene |
| Protein Tyrosine Phosphatase Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) Fas-Associated Protein-Tyrosine Phosphatase 1 Protein-Tyrosine Phosphatase 1E Protein-Tyrosine Phosphatase PTPL1 FAP-1 PNP1 PTP-BAS PTP1E PTPL1 hPTPE1 EC 3.1.3.48 PTP-BL PTPLE hPTP1E Tyrosine-Protein Phosphatase Non-Receptor Type 13 PTP-E1 |
| NCBI: 4q21.3 Ensembl: 4q21.3 |
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Subunit: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus) Sequence caution: Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTPN13 (see all 8): 1D5G (3D) [IMAGE] 1Q7X (3D) [IMAGE] 1WCH (3D) [IMAGE] 2M0Z (3D) [IMAGE] 2M10 (3D) [IMAGE] 3LNX (3D) [IMAGE]
Tissue specificity: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PTPN13: Protein Phosphatases in human mouse rat Primer Products:
Function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily Contains 1 FERM domain Contains 1 KIND domain Contains 5 PDZ (DHR) domains Contains 1 tyrosine-protein phosphatase domain [IMAGE]
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