TAG for PTPN3

Gene content

Symbol

PTPN3 ( by HUGO)

Name

Protein Tyrosine Phosphatase, Non-Receptor Type 3

Category

Tumor suppressor gene

Alias

Protein Tyrosine Phosphatase
Non-Receptor Type 3
PTPH1
Protein-Tyrosine Phosphatase H1
PTP-H1
EC 3.1.3.48
Cytoskeletal-Associated Protein Tyrosine Phosphatase
Tyrosine-Protein Phosphatase Non-Receptor Type 3

Cytogenetic band

NCBI: 9q31 Ensembl: 9q31.3

Protein information

PTN3_HUMAN

Size: 913 amino acids

Mass: 103990 Da

Function:

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Catalytic activity:

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Similarity:

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily

Contains 1 FERM domain

Contains 1 PDZ (DHR) domain

Contains 1 tyrosine-protein phosphatase domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000242	Tyr_Pase_rcpt/non-rcpt	Tyrosine specific protein phosphatase	Domain
	IPR000299	FERM_domain	Band 4.1	Domain
	IPR000387	Tyr/Dual-sp_Pase	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	Domain
	IPR001478	PDZ	PDZ/DHR/GLGF	Domain
	IPR011993	PH_like_dom	Pleckstrin homology-type	Domain
	IPR012151	Tyr_Pase_non-rcpt_typ-3/4	Protein-tyrosine phosphatase, non-receptor 3/4	Family
Blocks	IPB000242	Protein tyrosine phosphatase signature	Protein tyrosine phosphatase signature
	IPB000299	Band 4.1 domain	Band 4.1 domain
	IPB000798	ERM family signature	ERM family signature
	IPB001478	PDZ/DHR/GLGF domain	PDZ/DHR/GLGF domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	negative regulation of membrane protein ectodomain proteolysis	IMP	GOA	12207026
	negative regulation of mitotic cell cycle	IDA	GOA	10364224
	peptidyl-tyrosine dephosphorylation	TAS	GOA	1648725
	peptidyl-tyrosine dephosphorylation	IDA	GOA	19167335
	protein dephosphorylation	IDA	GOA	10364224
Cellular Component	cytoplasm	IDA	GOA	10940933
Cellular Component	cytoplasmic side of plasma membrane	IDA	GOA	10940933
Molecular Function	ATPase binding	IPI	GOA	10364224
	phosphotyrosine binding	IPI	GOA	10364224
	protein binding	IPI	GOA	10364224
	protein tyrosine phosphatase activity	IDA	GOA	19167335
	sodium channel regulator activity	IDA	GOA	16930557

PTPN3 cross reference