Gene content    
PTPRD ( by HUGO)
Protein Tyrosine Phosphatase, Receptor Type, D
Tumor suppressor gene
Protein Tyrosine Phosphatase
Receptor Type
D
R-PTP-delta
EC 3.1.3.48
HPTP
PTPD
HPTPD
HPTPDELTA
RPTPDELTA
Protein Tyrosine Phosphatase
Receptor Type
Delta Polypeptide
Receptor-Type Tyrosine-Protein Phosphatase Delta
Protein-Tyrosine Phosphatase Delta
NCBI: 9p23-p24.3    Ensembl: 9p23
PTPRD_HUMANSize: 1912 amino acidsMass: 214760 Da

  • Subunit: Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTPRD: 1X5Z (3D) [IMAGE] 2DLH (3D) [IMAGE] 2YD6 (3D) [IMAGE] 2YD7 (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: PTPRD_HUMAN, P23468
  • Catalytic activity:
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
  • Similarity:
    Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily
                          
    Contains 8 fibronectin type-III domains
                          
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains
                          
    Contains 2 tyrosine-protein phosphatase domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000242Tyr_Pase_rcpt/non-rcptTyrosine specific protein phosphataseDomain
    IPR000387Tyr/Dual-sp_PaseTyrosine specific protein phosphatase and dual specificity protein phosphataseDomain
    IPR003598Ig_sub2Immunoglobulin C2 typeDomain
    IPR003961Fibronectin_type3Fibronectin, type IIIDomain
    IPR007110Ig-like_domImmunoglobulin-likeDomain
    IPR013098Ig_I-setImmunoglobulin I-setDomain
    BlocksIPB000242Protein tyrosine phosphatase signatureProtein tyrosine phosphatase signature
    IPB003598Immunoglobulin C-2 typeImmunoglobulin C-2 type
    IPB003962Fibronectin type III repeat signatureFibronectin type III repeat signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process peptidyl-tyrosine dephosphorylation TAS GOA 7896816
    phosphate-containing compound metabolic process NAS GOA 7896816
    protein dephosphorylation TAS GOA 7896816
    transmembrane receptor protein tyrosine phosphatase signaling pathway TAS GOA 7896816
    Cellular Component integral component of plasma membrane TAS GOA 7896816
    Molecular Function protein binding IPI GOA 12570871
    transmembrane receptor protein tyrosine phosphatase activity TAS GOA 7896816

    PTPRD cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene