Gene content    
PTPRF ( by HUGO)
Protein Tyrosine Phosphatase, Receptor Type, F
Tumor suppressor gene
Protein Tyrosine Phosphatase
Receptor Type
F
LAR
Leukocyte Common Antigen Related
EC 3.1.3.48
LCA-homolog
Leukocyte Antigen-Related (LAR) PTP Receptor
Leukocyte Antigen-Related Tyrosine Phosphatase
Protein Tyrosine Phosphatase
Receptor Type
F Polypeptide
Receptor-Linked Protein-Tyrosine Phosphatase LAR
Receptor-Type Tyrosine-Protein Phosphatase F
NCBI: 1p34    Ensembl: 1p34.2
PTPRF_HUMANSize: 1907 amino acidsMass: 212879 Da

  • Subunit: Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR Sequence caution: Sequence=BAD66835.1; Type=Erroneous initiation; Sequence=CAA68754.1; Type=Erroneous initiation; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTPRF (see all 8): 1LAR (3D) [IMAGE] 2DJU (3D) [IMAGE] 2DN7 (3D) [IMAGE] 2EDX (3D) [IMAGE] 2EDY (3D) [IMAGE] 2YD5 (3D) [IMAGE]
  • Function:
    The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one
                          
    Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) Function: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one
  • Catalytic activity:
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
  • Similarity:
    Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily
                          
    Contains 8 fibronectin type-III domains
                          
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains
                          
    Contains 2 tyrosine-protein phosphatase domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000242Tyr_Pase_rcpt/non-rcptTyrosine specific protein phosphataseDomain
    IPR000387Tyr/Dual-sp_PaseTyrosine specific protein phosphatase and dual specificity protein phosphataseDomain
    IPR003598Ig_sub2Immunoglobulin C2 typeDomain
    IPR003961Fibronectin_type3Fibronectin, type IIIDomain
    IPR007110Ig-like_domImmunoglobulin-likeDomain
    IPR013098Ig_I-setImmunoglobulin I-setDomain
    BlocksIPB000242Protein tyrosine phosphatase signatureProtein tyrosine phosphatase signature
    IPB003598Immunoglobulin C-2 typeImmunoglobulin C-2 type
    IPB003962Fibronectin type III repeat signatureFibronectin type III repeat signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process transmembrane receptor protein tyrosine phosphatase signaling pathway TAS GOA 8995282
    Cellular Component extracellular vesicular exosome IDA GOA 19199708
    integral component of plasma membrane TAS GOA 2972792
    Molecular Function protein tyrosine phosphatase activity IDA GOA 10338209
    transmembrane receptor protein tyrosine phosphatase activity TAS GOA 8995282

    PTPRF cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene