Gene content    
PTPRG ( by HUGO)
Protein Tyrosine Phosphatase, Receptor Type, G
Tumor suppressor gene
Protein Tyrosine Phosphatase
Receptor Type
G
PTPG
Protein-Tyrosine Phosphatase Gamma
EC 3.1.3.48
HPTPG
H_RG317H01.1
R-PTP-GAMMA
RPTPG
Protein Tyrosine Phosphatase Gamma
Protein Tyrosine Phosphatase
Receptor Type
Gamma Polypeptide
Receptor Type Protein Tyrosine Phosphatase Gamma
Receptor Tyrosine Phosphatase Gamma
Receptor-Type Protein Phosphatase Gamma
Receptor-Type Tyrosine-Protein Phosphatase Gamma
R-PTP-gamma
NCBI: 3p21-p14    Ensembl: 3p14.2
PTPRG_HUMANSize: 1445 amino acidsMass: 162003 Da

  • Subunit: Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6 Sequence caution: Sequence=BAD93108.1; Type=Erroneous initiation; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for PTPRG (see all 18): 2H4V (3D) [IMAGE] 2HY3 (3D) [IMAGE] 2NLK (3D) [IMAGE] 2PBN (3D) [IMAGE] 3JXH (3D) [IMAGE] 3QCB (3D) [IMAGE]
  • Tissue specificity: Found in a variety of tissues [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PTPRG: Protein Phosphatases in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for PTPRG [IMAGE] Pre-validated RT2 qP
  • Function:
    Possesses tyrosine phosphatase activity
                          
    Possesses tyrosine phosphatase activity
  • Catalytic activity:
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
  • Similarity:
    Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily
                          
    Contains 1 alpha-carbonic anhydrase domain
                          
    Contains 1 fibronectin type-III domain
                          
    Contains 2 tyrosine-protein phosphatase domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000242Tyr_Pase_rcpt/non-rcptTyrosine specific protein phosphataseDomain
    IPR000387Tyr/Dual-sp_PaseTyrosine specific protein phosphatase and dual specificity protein phosphataseDomain
    IPR001148Carbonic_anhydrase_aCarbonic anhydrase, eukaryoticFamily
    IPR003961Fibronectin_type3Fibronectin, type IIIDomain
    BlocksIPB000242Protein tyrosine phosphatase signatureProtein tyrosine phosphatase signature
    IPB001148Carbonic anhydraseCarbonic anhydrase, eukaryotic

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process peptidyl-tyrosine dephosphorylation TAS GOA 8382771
    peptidyl-tyrosine dephosphorylation IDA GOA 19167335
    transmembrane receptor protein tyrosine kinase signaling pathway TAS GOA 8382771
    Cellular Component integral component of plasma membrane TAS GOA 8382771
    Molecular Function identical protein binding IPI GOA 19167335
    protein binding IPI GOA 19167335
    protein tyrosine phosphatase activity IDA GOA 19167335
    transmembrane receptor protein tyrosine phosphatase activity TAS GOA 8382771

    PTPRG cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene