Gene content
Symbol	PTPRK ( by HUGO)
Name	Protein Tyrosine Phosphatase, Receptor Type, K
Category	Tumor suppressor gene
Alias	Protein Tyrosine Phosphatase Receptor Type K Protein-Tyrosine Phosphatase Kappa R-PTP-kappa EC 3.1.3.48 DJ480J14.2.1 (Protein Tyrosine Phosphatase Receptor Type K (R-PTP-KAPPA Protein Tyrosine Phosphatase Kappa Protein Tyrosine Phosphatase Kappa Protein-Tyrosine Phosphatase Receptor Type Kappa Receptor-Type Tyrosine-Protein Phosphatase Kappa PTPK
Cytogenetic band	NCBI: 6q22.2-q22.3    Ensembl: 6q22.33
Protein information	PTPRK_HUMAN Size: 1439 amino acids Mass: 162102 Da Tissue specificity: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including PTPRK: Protein Phosphatases in human mouse rat Primer Products: [IMAGE] OriGe Function: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa                        Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily                        Contains 4 fibronectin type-III domains                        Contains 1 Ig-like C2-type (immunoglobulin-like) domain                        Contains 1 MAM domain                        Contains 2 tyrosine-protein phosphatase domains [IMAG

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000242	Tyr_Pase_rcpt/non-rcpt	Tyrosine specific protein phosphatase	Domain
	IPR000387	Tyr/Dual-sp_Pase	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	Domain
	IPR000998	MAM_dom	MAM	Domain
	IPR003599	Ig_sub	Immunoglobulin subtype	Domain
	IPR003961	Fibronectin_type3	Fibronectin, type III	Domain
	IPR007110	Ig-like_dom	Immunoglobulin-like	Domain
	IPR008985	ConA-like_lec_gl_sf	Concanavalin A-like lectin/glucanase	Domain
Blocks	IPB000242	Protein tyrosine phosphatase signature	Protein tyrosine phosphatase signature
	IPB000998	MAM domain signature	MAM domain signature
	IPB003599	Immunoglobulin subtype	Immunoglobulin subtype
	IPB003962	Fibronectin type III repeat signature	Fibronectin type III repeat signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell adhesion	IMP	GOA	15899872
	cell migration	IMP	GOA	15899872
	cellular response to reactive oxygen species	IDA	GOA	16849327
	cellular response to UV	IDA	GOA	16849327
	focal adhesion assembly	IMP	GOA	15899872
	negative regulation of cell cycle	IDA	GOA	15899872
	negative regulation of cell migration	IDA	GOA	18276111
	negative regulation of cell proliferation	IDA	GOA	15899872
	negative regulation of keratinocyte proliferation	IDA	GOA	16263724
	negative regulation of transcription, DNA-templated	IDA	GOA	18276111
	peptidyl-tyrosine dephosphorylation	NAS	GOA	9047348
	peptidyl-tyrosine dephosphorylation	IDA	GOA	16263724
	protein dephosphorylation	IDA	GOA	16263724
	protein localization to cell surface	IDA	GOA	18276111
	signal transduction	IDA	GOA	16849327
	transforming growth factor beta receptor signaling pathway	IDA	GOA	15899872
Cellular Component	cell surface	IDA	GOA	18276111
	cell-cell junction	IDA	GOA	8663237
	integral component of membrane	NAS	GOA	9047348
	integral component of plasma membrane	NAS	GOA	9047348
	leading edge membrane	IDA	GOA	15899872
Molecular Function	beta-catenin binding	IPI	GOA	8663237
	gamma-catenin binding	IPI	GOA	8663237
	protein binding	IPI	GOA	15899872
	protein kinase binding	IPI	GOA	15899872
	protein tyrosine phosphatase activity	IDA	GOA	16263724
	transmembrane receptor protein tyrosine phosphatase activity	NAS	GOA	9047348

PTPRK cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene