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Subunit: Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes. Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling. Interacts with MICAL1. Interacts with EHD1. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with RABIF, RIMS2, RPH3A and RPH3A. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO. Interacts with BIRC6/bruce. Interacts with OCRL Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RAB8A (see all 8): 3QBT (3D) [IMAGE] 3TNF (3D) [IMAGE] 4LHV (3D) [IMAGE] 4LHW (3D) [IMAGE] 4LHX (3D) [IMAGE] 4LHY (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: RAB8A_HUMAN, P61006 Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis Enzyme regulation: Activated in response to insulin (By similarity) Gene Ontology (GO): Selected molecular function terms (see all 6): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003924 GTPase activity EXP -- GO:0005515 protein binding IPI 15837803 GO:0005525 GTP binding IDA -- GO:0017137 Rab GTPase binding ISS -- GO:0019003 GDP binding IDA -- [IMAGE] Find genes that share ontologies with RAB8A About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for RAB8A: Decreased Hepatitis C virus re
Similarity: Belongs to the small GTPase superfamily. Rab family [IMAGE]
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