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Subunit: Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RALB: 2KE5 (3D) [IMAGE] 2KWI (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: RALB_HUMAN, P11234 Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
Similarity: Belongs to the small GTPase superfamily. Ras family [IMAGE]
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