Gene content  |
| RARB ( by HUGO) |
| Retinoic Acid Receptor, Beta |
| Tumor suppressor gene |
| Retinoic Acid Receptor Beta HAP Nuclear Receptor Subfamily 1 Group B Member 2 NR1B2 RAR-beta RAR-epsilon HBV-Activated Protein MCOPS12 RRB2 Hepatitis B Virus Activated Protein Retinoic Acid Receptor Beta Retinoic Acid Receptor Beta Polypeptide |
| NCBI: 3p24.2 Ensembl: 3p24.2 |
|
Subunit: Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts weakly with NCOR2 Sequence caution: Sequence=CAA27637.1; Type=Erroneous gene model prediction; 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RARB: 1HRA (3D) [IMAGE] 1XAP (3D) [IMAGE] 4DM6 (3D) [IMAGE] 4DM8 (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: RARB_HUMAN, P10826 Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function
Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily Contains 1 nuclear receptor DNA-binding domain [IMAGE]
|
| Protein Domain/Family |
| Source |
ID |
Domain |
Name |
Type |
| InterPro | IPR000536 | Nucl_hrmn_rcpt_lig-bd_core | Nuclear hormone receptor, ligand-binding | Domain
|
| IPR001628 | Znf_hrmn_rcpt | Nuclear hormone receptor, DNA-binding | Domain
|
| IPR001723 | Str_hrmn_rcpt | Steroid hormone receptor | Family
|
| IPR003078 | Retinoic_acid_rcpt | Retinoic acid receptor | Family
|
| IPR008946 | Nucl_hormone_rcpt_ligand-bd | Steroid nuclear receptor, ligand-binding | Domain
|
| Blocks | IPB001723 | Steroid hormone receptor signature | Steroid hormone receptor signature |
| IPB003078 | Retinoic acid receptor (1B nuclear receptor) signature | Retinoic acid receptor (1B nuclear receptor) signature |
