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Subunit: Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53 Sequence caution: Sequence=AAB67312.1; Type=Erroneous gene model prediction; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for RASSF1: 2KZU (3D) [IMAGE]
Tissue specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays i
Function: UniProtKB/Swiss-Prot Summary: RASF1_HUMAN, Q9NS23 Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 11857081 GO:0008270 zinc ion binding TAS 11333291 GO:0042802 identical protein binding IPI 11857081 GO:0047485 protein N-terminus binding IPI 18566590 [IMAGE] Find genes that share ontologies with RASSF1 About GenesLikeMe Phenotypes:
Similarity: Contains 1 phorbol-ester/DAG-type zinc finger Contains 1 Ras-associating domain Contains 1 SARAH domain [IMAGE]
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