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Subunit: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect Sequence caution: Sequence=BAG59728.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59871.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG63975.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Tissue specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines [IMAGE] Custom PCR Arrays for RBM5 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for RBM5 [IMAGE] Pre-validated RT2 qP
Function: UniProtKB/Swiss-Prot Summary: RBM5_HUMAN, P52756 Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis
Similarity: Belongs to the RBM5/RBM10 family Contains 1 C2H2-type zinc finger Contains 1 G-patch domain Contains 1 RanBP2-type zinc finger Contains 2 RRM (RNA recognition motif) domains [IMAGE]
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