Gene content    
RFP (approved by HUGO)
ret finger protein
Oncogene
RNF76
TRIM27
NCBI: 6p22    Ensembl: 6p22.1
TRI27_HUMANSize: 513 amino acidsMass: 58490 Da

  • Subcellular location: Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies
  • Subunit: Homomultimerizes. Interacts with PML, EIF3S6, EPC1, and CHD4
  • Tissue specificity: Expressed in testis namely within the seminiferous tubules
  • Function:
    Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity)
  • Similarity:
    Belongs to the TRIM/RBCC family
                          
    Contains 1 B box-type zinc finger
                          
    Contains 1 B30.2-like domain
                          
    Contains 1 RING-type zinc finger.

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000315Znf_BboxZinc finger, B-boxDomain
    IPR001841Znf_RINGZinc finger, RING-typeDomain
    IPR001870B302B302, (SPRY)-likeDomain
    IPR003877SPRY_receptorSPla/RYanodine receptor SPRYDomain
    IPR003879ButyrophylinButyrophylin-likeDomain
    IPR006574PRYSPRY-associatedDomain
    BlocksIPB000315B-box zinc finger signatureB-box zinc finger signature
    IPB003877SPla/RYanodine receptor SPRYSPla/RYanodine receptor SPRY
    IPB003879Butyrophylin C-terminal DUF signatureButyrophylin C-terminal DUF signature
    IPB006574SPRY-associated domainSPRY-associated domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA PubMed
    DNA binding IEA GOA
    metal ion binding TAS GOA PubMed
    nucleus IEA GOA
    protein binding IEA GOA
    spermatogenesis TAS GOA PubMed
    transmembrane receptor protein tyrosine kinase activity TAS GOA PubMed
    zinc ion binding IEA GOA
    Molecular Function integral to plasma membrane TAS GOA PubMed
    intracellular IEA GOA
    membrane fraction TAS GOA PubMed
    regulation of transcription, DNA-dependent IEA GOA
    transcription IEA GOA

    Disorder & Mutation    
    Source Disease
    SWISS-PROTA chomosomal aberration involving RFP is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates RFP/RET and delta RFP/RET oncogenes

    RFP cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene