Gene content
Symbol	RFP2 (approved by HUGO)
Name	ret finger protein 2
Category	Tumor suppressor gene
Alias	CAR LEU5 Leu5 RNF77 TRIM13
Cytogenetic band	NCBI: 13q14    Ensembl: --
Protein information	RFP2_HUMAN Size: 407 amino acids Mass: 46988 Da Function: May act as a tumor suppressor Similarity: Belongs to the TRIM/RBCC family                        Contains 1 B box-type zinc finger                        Contains 1 RING-type zinc finger.

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000315	Znf_Bbox	Zinc finger, B-box	Domain
	IPR001841	Znf_RING	Zinc finger, RING-type	Domain
Blocks	IPB000315	B-box zinc finger signature	B-box zinc finger signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell cycle	IEA	GOA
	metal ion binding	IEA	GOA
	morphogenesis	TAS	GOA	PubMed
	negative regulation of progression through cell cycle	IEA	GOA
	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP	GOA	PubMed
	protein binding	IEA	GOA
	signal transducer activity	IMP	GOA	PubMed
	zinc ion binding	IEA	GOA
Molecular Function	intracellular	IEA	GOA

Disorder & Mutation
Source	Disease
SWISS-PROT	May be involved in B-cell chronic lymphocytic leukemia (B-CLL) with a 13q14 region deletion

RFP2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene