Gene content  |
| RGS2 ( by HUGO) |
| Regulator Of G-Protein Signaling |
| Other |
| Regulator Of G-Protein Signaling 2 24kDa G0S8 Cell Growth-Inhibiting Gene 31 Protein G0/G1 Switch Regulatory Protein 8 Regulator Of G-Protein Signalling 2 24kD Regulator Of G-Protein Signalling 2 24kDa Cell Growth-Inhibiting Protein 31 G0 To G1 Switch Regulatory 8 24kD Regulator Of G-Protein Signaling 2 |
| NCBI: 1q31 Ensembl: 1q31.2 |
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Subunit: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha) 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RGS2: 2AF0 (3D) [IMAGE] 2V4Z (3D) [IMAGE] 4EKC (3D) [IMAGE] 4EKD (3D) [IMAGE]
Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL) [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including RGS2: G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat Epithelial to Mesenchym
Function: UniProtKB/Swiss-Prot Summary: RGS2_HUMAN, P41220 Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein
Similarity: Contains 1 RGS domain [IMAGE]
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