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Subunit: Interacts with ARHGEF28 (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA. Interacts with ARHGDIB Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RHOA (see all 19): 1A2B (3D) [IMAGE] 1CC0 (3D) [IMAGE] 1CXZ (3D) [IMAGE] 1DPF (3D) [IMAGE] 1FTN (3D) [IMAGE] 1KMQ (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: RHOA_HUMAN, P61586 Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization Enzyme regulation: GTP hydrolysis is stimulated by ARHGAP30 Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003924 GTPase activity TAS 10436159 GO:0005515 protein binding IPI 10051605 GO:0005525 GTP binding IEA -- GO:0017022 myosin binding IPI 15644318 GO:0019904 protein domain specific binding -- -- [IMAGE] Find genes that share ontologies with RHOA About GenesLikeMe Phenotypes: 9 GenomeRNAi human phenotypes for RHOA: Decreased NANOG protein expres Decreased OCT4 protein express Decreased POU5F1-GFP protein e Decreased focal adhesion (FA) Decreased homologous recombina Increased Salmonella enterica Increased gamma-H2AX phosphory Stronger migration Upregulation of Wnt/beta-caten
Similarity: Belongs to the small GTPase superfamily. Rho family [IMAGE]
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