Gene content  |
| RHOB ( by HUGO) |
| Ras Homolog Family Member B |
| Oncogene |
| Ras Homolog Family Member B ARH6 ARHB Ras Homolog Gene Family Member B Oncogene RHO H6 Rho CDNA Clone 6 h6 RHOH6 MST081 MSTP081 Aplysia RAS-Related Homolog 6 Rho-Related GTP-Binding Protein RhoB |
| NCBI: 2p24 Ensembl: 2p24.1 |
|
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13 Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for RHOB: 2FV8 (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: RHOB_HUMAN, P62745 Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells
Similarity: Belongs to the small GTPase superfamily. Rho family [IMAGE]
|
