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Subunit: Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with GGA1
Tissue specificity: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skele
Function: UniProtKB/Swiss-Prot Summary: RNF11_HUMAN, Q9Y3C5 Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding TAS 10673045 GO:0005515 protein binding IPI 14755250 GO:0008270 zinc ion binding IEA -- GO:0046872 metal ion binding -- -- [IMAGE] Find genes that share ontologies with RNF11 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for RNF11: Downregulation of NF-kappaB pa Downregulation of NF-kappaB pa Increased cell death HMECs cel Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF11 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF11 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF11 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF11 miRNA Products: miRTarBase miRNAs that target RNF11: hsa-mir-340-5p (MIRT019648), hsa-mir-21-5p (MIRT031075), hsa-mir-24-3p (MIRT030623), hsa-mir-19b-3p (MIRT031299), hsa-mir-484 (MIRT042387) [IMAGE] Block miRNA regulation of human, mouse, rat RNF11 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate RNF11 (see all 26): hsa-miR-582-3p hsa-miR-498 hsa-miR-3194-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-3133 hsa-miR-29b-1* hsa-miR-9 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: RNF11 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for RNF11 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat RNF11 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for RNF11 Clone Products: [IMAGE] OriGene clones in human, mouse for RNF11 (see all 6) OriGene ORF clones in mouse, rat for RNF11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: RNF11 (NM_007148) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF11 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF11 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for RNF11 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for RNF11 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF11
Similarity: Contains 1 RING-type zinc finger [IMAGE]
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