Gene content    
RPS19 ( by HUGO)
Ribosomal Protein S19
Other
Ribosomal Protein S19
DBA
DBA1
Diamond-Blackfan Anemia
40S Ribosomal Protein S19
S19
NCBI: 19q13.2    Ensembl: 19q13.2
RS19_HUMANSize: 145 amino acidsMass: 16060 Da

  • Tissue specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon tissue [IMAGE] Custom PCR Arrays for RPS19 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for RPS19 OriGene qSTAR qPCR primer pairs in human, mouse
  • Function:
    UniProtKB/Swiss-Prot Summary: RS19_HUMAN, P39019 Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits
  • Similarity:
    Belongs to the ribosomal protein S19e family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001266Ribosomal_S19eRibosomal protein S19eFamily
    BlocksIPB001266Ribosomal protein S19eRibosomal protein S19e

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process erythrocyte differentiation IMP GOA 16289379
    maturation of SSU-rRNA IMP GOA 16990592
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP GOA 16990592
    monocyte chemotaxis IDA GOA 11226885
    negative regulation of respiratory burst involved in inflammatory response IDA GOA 15750715
    nucleolus organization IMP GOA 17053056
    positive regulation of cellular component movement TAS GOA 16289379
    positive regulation of respiratory burst involved in inflammatory response IDA GOA 15750715
    protein tetramerization IDA GOA 11226885
    response to extracellular stimulus TAS GOA 16289379
    ribosomal small subunit assembly IMP GOA 17053056
    ribosomal small subunit biogenesis IMP GOA 18697920
    rRNA processing IMP GOA 18697920
    translation IC GOA 8706699
    Cellular Component cytoplasm IDA GOA 17517689
    cytosol IDA GOA 11716516
    cytosolic small ribosomal subunit IDA GOA 15883184
    membrane IDA GOA 19946888
    nucleolus IDA GOA 12586610
    ribosome IDA GOA 17517689
    Molecular Function fibroblast growth factor binding IPI GOA 11716516
    protein binding IPI GOA 16266891
    protein homodimerization activity IDA GOA 11226885
    protein kinase binding IPI GOA 16266891
    structural constituent of ribosome IDA GOA 15883184

    Disorder & Mutation    
    Source Disease
    SWISS-PROTDiamond-Blackfan anemia 1 (DBA1) [MIM:105650]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry

    RPS19 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene