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Subunit: Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression Sequence caution: Sequence=AAH05850.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA03247.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for RUNX1T1 (see all 9): 1WQ6 (3D) [IMAGE] 2DJ8 (3D) [IMAGE] 2H7B (3D) [IMAGE] 2KNH (3D) [IMAGE] 2KYG (3D) [IMAGE] 2OD1 (3D) [IMAGE]
Tissue specificity: Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including RUNX1T1: Adipogenesis in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template s
Function: UniProtKB/Swiss-Prot Summary: MTG8_HUMAN, Q06455 Function: Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12 Gene Ontology (GO): Selected molecular function terms (see all 6): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity IEA -- GO:0005515 protein binding IPI 10973986 GO:0042802 identical protein binding IPI 16616331 GO:0042803 protein homodimerization activity IEA -- [IMAGE] Find genes that share ontologies with RUNX1T1 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for RUNX1T1: Increased G2M DNA content
Similarity: Belongs to the CBFA2T family Contains 1 MYND-type zinc finger Contains 1 TAFH (NHR1) domain [IMAGE]
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