TAG for RUNX3

Gene content

Symbol

RUNX3 ( by HUGO)

Name

Runt-Related Transcription Factor 3

Category

Tumor suppressor gene

Alias

Runt-Related Transcription Factor 3
CBFA3
AML2
Acute Myeloid Leukemia 2 Protein
Core-Binding Factor Subunit Alpha-3
Oncogene AML-2
Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit
CBF-alpha-3
PEA2-Alpha C
PEBP2-Alpha C
SL3-3 Enhancer Factor 1 Alpha C Subunit
SL3/AKV Core-Binding Factor Alpha C Subunit
PEBP2A3
PEBP2aC
Acute Myeloid Leukemia Gene 2
Core-Binding Factor
Runt Domain
Alpha Subunit 3
PEA2 Alpha C
PEBP2 Alpha C
Transcription Factor AML2

Cytogenetic band

NCBI: 1p36 Ensembl: 1p36.11

Protein information

RUNX3_HUMAN

Size: 415 amino acids

Mass: 44356 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK

Function:

UniProtKB/Swiss-Prot Summary: RUNX3_HUMAN, Q13761 Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters

Similarity:

Contains 1 Runt domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000040	AML1_Runt	Acute myeloid leukemia 1 protein (AML 1)/Runt	Family
	IPR008967	p53-like_TF_DNA-bd	p53-like transcription factor, DNA-binding	Domain
	IPR012346	p53/RUNT-type_TF_DNA-bd	p53 and RUNT-type transcription factor, DNA-binding	Domain
Blocks	IPB000040	Acute myeloid leukemia 1 protein signature	Acute myeloid leukemia 1 protein signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	regulation of transcription, DNA-templated	NAS	GOA	7622058
Biological Process	transcription from RNA polymerase II promoter	TAS	GOA	7607690
Molecular Function	ATP binding	NAS	GOA	7835892
	protein binding	IPI	GOA	18772112
	sequence-specific DNA binding transcription factor activity	TAS	GOA	7607690

RUNX3 cross reference