Gene content    
S100A2 ( by HUGO)
S100 Calcium Binding Protein A2
Tumor suppressor gene
S100 Calcium Binding Protein A2
S100L
S100 Calcium-Binding Protein A2
CAN19
Protein S100-A2
Protein S-100L
NCBI: 1q21    Ensembl: 1q21.3
S10A2_HUMANSize: 98 amino acidsMass: 11117 Da

  • Subunit: Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity Developmental stage: Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression Miscellaneous: This protein binds two calcium ions (By similarity) Caution: It is uncertain whether Met-1 or Met-2 is the initiator Sequence caution: Sequence=CAA69033.1; Type=Erroneous initiation; Note=Translation N-terminally extended; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for S100A2: 2RGI (3D) [IMAGE] 4DUQ (3D) [IMAGE]
  • Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes [IMAGE] Custom PCR Arrays for S100A2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for S100A2 OriGene qSTAR qPCR primer pairs in hum
  • Function:
    UniProtKB/Swiss-Prot Summary: S10A2_HUMAN, P29034 Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth
  • Similarity:
    Belongs to the S-100 family
                          
    Contains 2 EF-hand domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001751S100/CaBP-9k_CSCalcium-binding protein, S-100/ICaBP typeDomain
    IPR002048EF_hand_domCalcium-binding EF-handDomain
    IPR011992EF-hand-dom_pairEF-Hand typeDomain
    BlocksIPB001751Calcium-binding proteinCalcium-binding protein, S-100/ICaBP type

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process endothelial cell migration IMP GOA 15313892
    Molecular Function calcium ion binding NAS GOA 9481475
    identical protein binding IPI GOA 16189514

    S100A2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene