Gene content    
SALL4 ( by HUGO)
Spalt-Like Transcription Factor 4
Oncogene
Spalt-Like Transcription Factor 4
Zinc Finger Protein 797
Zinc Finger Protein SALL4
ZNF797
HSAL4
Sal (Drosophila)-Like 4
Sal-Like 4 (Drosophila)
DRRS
dJ1112F19.1
Sal-Like Protein 4
NCBI: 20q13.2    Ensembl: 20q13.2
SALL4_HUMANSize: 1053 amino acidsMass: 112231 Da

  • Subunit: Interacts with NANOG (By similarity). Interacts with POU5F1/OCT4
  • Tissue specificity: Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML) [IMAGE] Custom PCR Arrays for SALL4 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for SALL4 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mous
  • Function:
    UniProtKB/Swiss-Prot Summary: SALL4_HUMAN, Q9UJQ4 Function: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding -- -- GO:0003677 DNA binding IEA -- GO:0005515 protein binding -- -- GO:0046872 metal ion binding IEA -- [IMAGE] Find genes that share ontologies with SALL4 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for SALL4: G2 arrest Increased G2M DNA content Selected MGI mutant phenotypes (inferred from 13 alleles[IMAGE]) (MGI details for Sall4) (see all 16): behavior/neurological cardiovascular system cellular craniofacial digestive/alimentary embryogenesis growth/size/body hearing/vestibular/ear immune system limbs/digits/tail mortality/aging nervous system renal/urinary system reproductive system skeleton [IMAGE] Find genes that share phenotypes with SALL4 About GenesLikeMe Animal Models: MGI mouse knock-outs for SALL4: Sall4tm1Bili Sall4tm1Ryn Sall4tm2.1Tre Sall4tm1Tre Sall4tm4Ryn Sall4tm1Brd [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SALL4 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SALL4 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SALL4 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SALL4 miRNA Products: miRTarBase miRNAs that target SALL4: hsa-mir-335-5p (MIRT016935) [IMAGE] Block miRNA regulation of human, mouse, rat SALL4 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate SALL4 (see all 15): hsa-miR-579 hsa-miR-15a hsa-miR-497 hsa-miR-219-5p hsa-miR-507 hsa-miR-103a hsa-miR-508-3p hsa-miR-424 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: SALL4 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for SALL4 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat SALL4 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for SALL4 Clone Products: [IMAGE] OriGene clones in human, mouse for SALL4 (see all 8) OriGene ORF clones in mouse, rat for SALL4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: SALL4 (NM_020436) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for SALL4 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SALL4 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for SALL4 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for SALL4 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SALL4
  • Similarity:
    Belongs to the sal C2H2-type zinc-finger protein family
                          
    Contains 7 C2H2-type zinc fingers [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007087Znf_C2H2Zinc finger, C2H2-typeDomain

    Disorder & Mutation    
    Source Disease
    SWISS-PROTDuane-radial ray syndrome (DRRS) [MIM:607323]: Disorder characterized by the association of forearm malformations with Duane retraction syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
    SWISS-PROTOculootoradial syndrome (OORS) [MIM:147750]: Autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome (DRRS) with a similar phenotype. Note=The disease is caused by mutations affecting the gene represented in this entry

    SALL4 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene