Gene content  |
| SEMA3E ( by HUGO) |
| Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,... |
| Other |
| Sema Domain Immunoglobulin Domain (Ig) Short Basic Domain Secreted (Semaphorin) 3E SEMAH KIAA0331 M-Sema H M-SEMAH M-SemaK coll-5 semaphorin-3E |
| NCBI: 7q21.11 Ensembl: 7q21.11 |
|
Subunit: Interacts with PLXND1 (By similarity) Sequence caution: Sequence=BAA20789.2; Type=Erroneous initiation;
Function: UniProtKB/Swiss-Prot Summary: SEM3E_HUMAN, O15041 Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity) [IMAGE]Summary: [IMAGE] During embryonic development, SEMA3E as signaling molecule affects the following cells: Endothelium: Endothelial Tip Cells (Arteries) Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity IEA -- GO:0005515 protein binding IPI 17318185 [IMAGE] Find genes that share ontologies with SEMA3E About GenesLikeMe Phenotypes:
Similarity: Belongs to the semaphorin family Contains 1 Ig-like C2-type (immunoglobulin-like) domain Contains 1 Sema domain [IMAGE]
|
