Gene content  |
| SERPINB5 ( by HUGO) |
| Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member... |
| Tumor suppressor gene |
| Serpin Peptidase Inhibitor Clade B (Ovalbumin) Member 5 PI5 Serine (Or Cysteine) Proteinase Inhibitor Clade B (Ovalbumin) Member 5 Protease Inhibitor 5 (Maspin) Peptidase Inhibitor 5 PI-5 maspin Serpin B5 Maspin |
| NCBI: 18q21.33 Ensembl: 18q21.33 |
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Subunit: Interacts with IRF6 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for SERPINB5: 1WZ9 (3D) [IMAGE] 1XQG (3D) [IMAGE] 1XQJ (3D) [IMAGE] 1XU8 (3D) [IMAGE]
Tissue specificity: Normal mammary epithelial cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINB5: Oncogenes & Tumor Suppressor Genes in human mouse rat p53 Signaling Pathway in human mouse rat Angiogenesis in human mouse rat Primer Products: [
Function: UniProtKB/Swiss-Prot Summary: SPB5_HUMAN, P36952 Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004867 serine-type endopeptidase inhibitor activity IBA -- GO:0005515 protein binding IPI 16049006 [IMAGE] Find genes that share ontologies with SERPINB5 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for SERPINB5: Decreased number of cells in m Synthetic lethal with Ras
Similarity: Belongs to the serpin family. Ov-serpin subfamily [IMAGE]
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