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Subunit: Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes Developmental stage: Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases Sequence caution: Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Tissue specificity: Expressed in adipose tissue [IMAGE] Custom PCR Arrays for SERTAD2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for SERTAD2 OriGene qSTAR qPCR primer pairs in human, mouse for SERTAD2 [IMAGE] Pre-validated RT2 qPCR Primer Assay
Function: UniProtKB/Swiss-Prot Summary: SRTD2_HUMAN, Q14140 Function: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003713 transcription coactivator activity IEA -- GO:0005515 protein binding -- -- [IMAGE] Find genes that share ontologies with SERTAD2 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for SERTAD2: Decreased NANOG protein expres Decreased OCT4 protein express Decreased POU5F1-GFP protein e
Similarity: Contains 1 SERTA domain [IMAGE]
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