Gene content  |
| SFRP4 ( by HUGO) |
| Secreted Frizzled-Related Protein 4 |
| Other |
| Secreted Frizzled-Related Protein 4 FRPHE Frizzled Protein Human Endometrium sFRP-4 FRP-4 Secreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4 FrpHE |
| NCBI: 7p14.1 Ensembl: 7p14.1 |
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Tissue specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, exp
Function: UniProtKB/Swiss-Prot Summary: SFRP4_HUMAN, Q6FHJ7 Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake
Similarity: Belongs to the secreted frizzled-related protein (sFRP) family Contains 1 FZ (frizzled) domain Contains 1 NTR domain [IMAGE]
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