Gene content    
SFRP5 ( by HUGO)
Secreted Frizzled-Related Protein 5
Tumor suppressor gene
Secreted Frizzled-Related Protein 5
SARP3
Secreted Apoptosis Related Protein 3
Frizzled-Related Protein 1b
Secreted Apoptosis-Related Protein 3
FRP-1b
SARP-3
sFRP-5
FRP1B
NCBI: 10q24.1    Ensembl: 10q24.2
SFRP5_HUMANSize: 317 amino acidsMass: 35563 Da

  • Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP5: Leukemia in human mouse rat WNT Signaling Pathway in human mouse r
  • Function:
    UniProtKB/Swiss-Prot Summary: SFRP5_HUMAN, Q5T4F7 Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina
  • Similarity:
    Belongs to the secreted frizzled-related protein (sFRP) family
                          
    Contains 1 FZ (frizzled) domain
                          
    Contains 1 NTR domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001134Netrin_domainNetrin, C-terminalDomain
    IPR008993TIMP-like_OB-foldTIMP-like OB-foldDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process anatomical structure morphogenesis TAS GOA 10072424
    apoptotic process TAS GOA 9391078
    establishment or maintenance of cell polarity TAS GOA 10072424
    negative regulation of canonical Wnt signaling pathway IMP GOA 19957335
    negative regulation of catenin import into nucleus IMP GOA 19957335
    negative regulation of cell proliferation IMP GOA 19957335
    negative regulation of protein kinase B signaling IMP GOA 19957335
    negative regulation of sequence-specific DNA binding transcription factor activity IMP GOA 19957335
    negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis IMP GOA 18981481
    signal transduction TAS GOA 10072424
    visual perception TAS GOA 10072424
    Cellular Component extracellular space TAS GOA 10072424

    SFRP5 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene