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Subunit: Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (By similarity). Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for SIN3A: 1PO4 (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: SIN3A_HUMAN, Q96ST3 Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation Gene Ontology (GO): Selected molecular function terms (see all 11): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0001102 RNA polymerase II activating transcription factor binding IPI -- GO:0001103 RNA polymerase II repressing transcription factor binding IEA -- GO:0001106 RNA polymerase II transcription corepressor activity IEA -- GO:0003677 DNA binding IEA -- GO:0003682 chromatin binding IEA -- [IMAGE] Find genes that share ontologies with SIN3A About GenesLikeMe Phenotypes:
Similarity: Contains 3 PAH (paired amphipathic helix) domains [IMAGE]
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