Gene content  |
| SKI ( by HUGO) |
| V-Ski Avian Sarcoma Viral Oncogene Homolog |
| Oncogene |
| V-Ski Avian Sarcoma Viral Oncogene Homolog Proto-Oncogene C-Ski SGS SKV Ski Oncogene Ski Oncoprotein |
| NCBI: 1p36.33 Ensembl: 1p36.33 |
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Subunit: Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for SKI: 1MR1 (3D) [IMAGE] 1SBX (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: SKI_HUMAN, P12755 Function: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling
Similarity: Belongs to the SKI family [IMAGE]
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