Gene content
Symbol	SKIL ( by HUGO)
Name	SKI-Like Oncogene
Category	Oncogene
Alias	SKI-Like Oncogene SNO SnoA SnoI SnoN Ski-Like Protein Ski-Related Oncogene SnoN Ski-Related Oncogene Ski-Related Protein
Cytogenetic band	NCBI: 3q26    Ensembl: 3q26.2
Protein information	SKIL_HUMAN Size: 684 amino acids Mass: 76976 Da Subunit: Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for SKIL: 3EQ5 (3D) [IMAGE] Tissue specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle [IMAGE] Pathway & D Function: UniProtKB/Swiss-Prot Summary: SKIL_HUMAN, P12757 Function: May have regulatory role in cell division or differentiation in response to extracellular signals Gene Ontology (GO): Selected molecular function terms (see all 8): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding -- -- GO:0003677 NOT DNA binding IDA 10531062 GO:0003682 chromatin binding ISS -- GO:0003714 transcription corepressor activity IDA 10531062 GO:0005515 protein binding IPI 10049357 [IMAGE] Find genes that share ontologies with SKIL About GenesLikeMe Phenotypes: Similarity: Belongs to the SKI family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR003380	Transform_Ski	Transforming protein Ski	Family
	IPR009061	DNA-bd_dom_put	Putative DNA binding	Domain
	IPR010919	SAND_dom-like	SAND-like	Domain
Blocks	IPB003380	Transforming protein Ski	Transforming protein Ski

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	negative regulation of transcription from RNA polymerase II promoter	IDA	GOA	10531062
	negative regulation of transforming growth factor beta receptor signaling pathway	IDA	GOA	17469184
	positive regulation of axonogenesis	IMP	GOA	16675394
	protein heterotrimerization	IDA	GOA	8514802
	protein homotrimerization	IDA	GOA	8514802
	response to antibiotic	IEP	GOA	15967445
	response to growth factor	IDA	GOA	19383336
	skeletal muscle tissue development	IDA	GOA	17202138
Cellular Component	cytoplasm	IDA	GOA	16109768
	nucleus	IDA	GOA	14712482
	PML body	IDA	GOA	19383336
Molecular Function	NOT DNA binding	IDA	GOA	10531062
	protein binding	IPI	GOA	10049357
	protein complex binding	IDA	GOA	18334480
	protein domain specific binding	IPI	GOA	18334480
	SMAD binding	IPI	GOA	12764135
	transcription corepressor activity	IDA	GOA	10531062

SKIL cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene