TAG for SKIV2L

Gene content

Symbol

SKIV2L ( by HUGO)

Name

Superkiller Viralicidic Activity

Category

Other

Alias

Superkiller Viralicidic Activity 2-Like (S. Cerevisiae)
SKIV2
SKI2W
Helicase-Like Protein
DDX13
HLP
SKI2
THES2
Superkiller Viralicidic Activity 2 (S. Cerevisiae Homolog)-Like
170A
Helicase SKI2W
EC 3.6.4.-
Ski2
W
EC 3.6.1

Cytogenetic band

NCBI: 6p21 Ensembl: 6p21.33

Protein information

SKIV2_HUMAN

Size: 1246 amino acids

Mass: 137755 Da

Subunit: Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 Sequence caution: Sequence=AAB52523.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Function:

UniProtKB/Swiss-Prot Summary: SKIV2_HUMAN, Q15477 Function: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)

Similarity:

Belongs to the helicase family. SKI2 subfamily

Contains 1 helicase ATP-binding domain

Contains 1 helicase C-terminal domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001650	Helicase_C	Helicase, C-terminal	Domain
	IPR011545	DNA/RNA_helicase_DEAD/DEAH_N	DEAD/DEAH box helicase, N-terminal	Domain
	IPR012961	DSH_C	DSH, C-terminal	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	ATP catabolic process	TAS	GOA	7610041
Cellular Component	Ski complex	IDA	GOA	16024656
Molecular Function	ATP-dependent RNA helicase activity	TAS	GOA	7610041

Disorder & Mutation
Source	Disease
SWISS-PROT	Trichohepatoenteric syndrome 2 (THES2) [MIM:614602]: A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients. Note=The disease is caused by mutations affecting the gene represented in this entry

SKIV2L cross reference